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Watch Closely (1)pentobarbital will lower the extent or impact of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or impact of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will lower the extent or impact of guanfac